Hades ruled the Underworld and the wealth of the earth. He was most known for carrying a trident and dishing out his vengeance or help to wayward sailors. He was responsible for earthquakes, floods, and terrible sea storms. And, whereas Zeus ruled the sky, Poseidon ruled over the sea and horses. He was most known for his lightning bolt and judgement over other gods and mortals. He was the most influential in winning the battle against Cronus. Zeus was said to be the King of the gods. Their relationships, families, events, and the outcomes of those events were also influenced by the part of the world in which they ruled. The places where each brother ruled shaped their personality and abilities. Drawing lots, it was decided Zeus would be ruler of the heavens, Poseidon would be ruler of the sea, and Hades would be ruler of the Underworld. This came about when a decision made after the brothers had beaten their father, Cronus, and the other Titans-gods in a great battle. Zeus, Poseidon and Hades were responsible for their own part of the Greek universe. So what is the difference between Zeus, Poseidon, and Hades? They are considered to be three major Greek gods, but that is where their similarities end. Zeus, Poseidon, and Hades were all known to be the sons of Cronus and Rhea.
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The explosion of new products for the treatment of haemophilia will hopefully benefit all patients and change the current landscape from shortage, allowing only limited dosing in prophylactic regimens, to one of plenty. Now the landscape is changing dramatically. The Swedish and the Dutch groups have published the most comprehensive data on long term outcome with life-long prophylaxis. 1 Patients having access to primary prophylaxis are growing up without or with very limited joint problems. To prevent joint disease prophylaxis should be started very early, preferably after no more than 1-2 joint bleeds. Prophylaxis aimed at the prevention of bleeds is now globally accepted as the superior therapy. Only countries in the developed world with health-care systems that reimbursed the costs of treatment were able to start prophylaxis-based treatment regimens. Therefore, patients had no access to treatment at home and treatment was only delivered after long delays and more often not at all. 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